Drug interactions: Grapefruit juice inhibits digestive enzymes. This can disrupt drug metabolism and increase blood drug levels.
Increased drug potency: Drug interactions can increase drug potency, causing side effects or toxicity at safe doses.
Drug effectiveness: Grapefruit juice may diminish the efficacy of several drugs, lowering plasma levels and compromising therapeutic effects.
Grapefruit juice may disrupt the metabolism of hormonal drugs like birth control pills, lowering their levels and potency.
Due of grapefruit juice's acidity, some people may feel bloating, gas, or stomach irritation.
Allergic reactions: Grapefruit or its components can cause itching, hives, or anaphylaxis in rare situations.
Increased sun sensitivity: Grapefruit juice includes chemicals that may make delicate skin more susceptible to sunburn or irritation.
Increased grapefruit juice drinking may cause kidney stones in susceptible people due to its high oxalate content.